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<link:definition>1003 - Statement - Consolidated Statements of Profit or Loss and Other Comprehensive Income (Parenthetical)</link:definition>
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<link:definition>1004 - Statement - Consolidated Statements of Financial Position</link:definition>
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<link:definition>1005 - Statement - Consolidated Statements of Changes in Equity</link:definition>
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<link:definition>1006 - Statement - Consolidated Cash Flow Statements</link:definition>
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<link:definition>1007 - Disclosure - General Information</link:definition>
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<link:definition>1008 - Disclosure - Summary of Significant Accounting Policies</link:definition>
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<link:definition>1009 - Disclosure - Significant Accounting Judgements and Estimates</link:definition>
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<link:definition>1010 - Disclosure - Revenue</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1011 - Disclosure - Segment Information</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1012 - Disclosure - Employee costs</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1013 - Disclosure - Share-based Payment</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1014 - Disclosure - Principal Accountant Fees and Services</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1015 - Disclosure - Tax on Profit/(Loss) for the Year and Deferred Tax</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1016 - Disclosure - Intangible Assets</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1017 - Disclosure - Property, Plant and Equipment</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1018 - Disclosure - Investment in Associate</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1019 - Disclosure - Inventories</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1020 - Disclosure - Leases</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1021 - Disclosure - Contract liabilities</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1022 - Disclosure - Commitments and Contingencies</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
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<link:definition>1023 - Disclosure - Financial Risk Management and Financial Instruments</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1024 - Disclosure - Related Party Transactions</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://ascendispharma.com/role/InvestmentsInGroupEnterprises" id="InvestmentsInGroupEnterprises">
<link:definition>1025 - Disclosure - Investments in Group Enterprises</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1026 - Disclosure - Ownership</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1027 - Disclosure - Subsequent Events</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SummaryOfSignificantAccountingPoliciesPolicies" id="SummaryOfSignificantAccountingPoliciesPolicies">
<link:definition>1028 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SummaryOfSignificantAccountingPoliciesTables" id="SummaryOfSignificantAccountingPoliciesTables">
<link:definition>1029 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://ascendispharma.com/role/RevenueTables" id="RevenueTables">
<link:definition>1030 - Disclosure - Revenue (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
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<link:definition>1031 - Disclosure - Segment Information (Tables)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1032 - Disclosure - Employee Cost (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://ascendispharma.com/role/ShareBasedPaymentTables" id="ShareBasedPaymentTables">
<link:definition>1033 - Disclosure - Share-based Payment (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://ascendispharma.com/role/PrincipalAccountantFeesAndServicesTables" id="PrincipalAccountantFeesAndServicesTables">
<link:definition>1034 - Disclosure - Principal Accountant Fees and Services (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
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<link:definition>1035 - Disclosure - Tax on Profit/(Loss) for the Year and Deferred Tax (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://ascendispharma.com/role/IntangibleAssetsTables" id="IntangibleAssetsTables">
<link:definition>1036 - Disclosure - Intangible Assets (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/PropertyPlantAndEquipmentTables" id="PropertyPlantAndEquipmentTables">
<link:definition>1037 - Disclosure - Property, Plant and Equipment (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/InvestmentInAssociateTables" id="InvestmentInAssociateTables">
<link:definition>1038 - Disclosure - Investment in Associate (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/InventoriesTables" id="InventoriesTables">
<link:definition>1039 - Disclosure - Inventories (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/LeasesTables" id="LeasesTables">
<link:definition>1040 - Disclosure - Leases (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/FinancialRiskManagementAndFinancialInstrumentsTables" id="FinancialRiskManagementAndFinancialInstrumentsTables">
<link:definition>1041 - Disclosure - Financial Risk Management and Financial Instruments (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/InvestmentsInGroupEnterprisesTables" id="InvestmentsInGroupEnterprisesTables">
<link:definition>1042 - Disclosure - Investments in Group Enterprises (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SummaryOfSignificantAccountingPoliciesAdditionalInformationDetail" id="SummaryOfSignificantAccountingPoliciesAdditionalInformationDetail">
<link:definition>1043 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfAssetsExpectedUsefulLifeDetail" id="SummaryOfSignificantAccountingPoliciesScheduleOfAssetsExpectedUsefulLifeDetail">
<link:definition>1044 - Disclosure - Summary of Significant Accounting Policies - Schedule of Asset's Expected Useful Life (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SignificantAccountingJudgementsAndEstimatesAdditionalInformationDetail" id="SignificantAccountingJudgementsAndEstimatesAdditionalInformationDetail">
<link:definition>1045 - Disclosure - Significant Accounting Judgements and Estimates - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://ascendispharma.com/role/RevenueAdditionalInformationDetail" id="RevenueAdditionalInformationDetail">
<link:definition>1046 - Disclosure - Revenue - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/RevenueScheduleOfRevenueRecognizedInConsolidatedStatementsOfProfitOrLossDetail" id="RevenueScheduleOfRevenueRecognizedInConsolidatedStatementsOfProfitOrLossDetail">
<link:definition>1047 - Disclosure - Revenue - Schedule of Revenue Recognized in Consolidated Statements of Profit or Loss (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/RevenueScheduleOfRevenueRecognizedInConsolidatedStatementsOfProfitOrLossParentheticalDetail" id="RevenueScheduleOfRevenueRecognizedInConsolidatedStatementsOfProfitOrLossParentheticalDetail">
<link:definition>1048 - Disclosure - Revenue - Schedule of Revenue Recognized in Consolidated Statements of Profit or Loss (Parenthetical) (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SegmentInformationAdditionalInformationDetail" id="SegmentInformationAdditionalInformationDetail">
<link:definition>1049 - Disclosure - Segment Information - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/SegmentInformationSummaryOfIntangibleAssetsAndPropertyPlantAndEquipmentDetail" id="SegmentInformationSummaryOfIntangibleAssetsAndPropertyPlantAndEquipmentDetail">
<link:definition>1050 - Disclosure - Segment Information - Summary of Intangible Assets, and Property, Plant and Equipment (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/EmployeeCostSummaryOfEmployeeCostDetail" id="EmployeeCostSummaryOfEmployeeCostDetail">
<link:definition>1051 - Disclosure - Employee Cost - Summary of Employee Cost (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/EmployeeCostAdditionalInformationDetail" id="EmployeeCostAdditionalInformationDetail">
<link:definition>1052 - Disclosure - Employee Cost - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/EmployeeCostWarrantActivityAdditionalInformationDetail" id="EmployeeCostWarrantActivityAdditionalInformationDetail">
<link:definition>1053 - Disclosure - Employee Cost - Warrant Activity - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/ShareBasedPaymentScheduleOfWarrantActivityDetail" id="ShareBasedPaymentScheduleOfWarrantActivityDetail">
<link:definition>1054 - Disclosure - Share-based Payment - Schedule of Warrant Activity (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/ShareBasedPaymentScheduleOfWarrantActivityParentheticalDetail" id="ShareBasedPaymentScheduleOfWarrantActivityParentheticalDetail">
<link:definition>1055 - Disclosure - Share-based Payment  - Schedule of Warrant Activity (Parenthetical) (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/ShareBasedPaymentScheduleOfWeightedAverageExercisePriceAndWeightedRemainingContractualLifeForOutstandingWarrantsDetail" id="ShareBasedPaymentScheduleOfWeightedAverageExercisePriceAndWeightedRemainingContractualLifeForOutstandingWarrantsDetail">
<link:definition>1056 - Disclosure - Share-based Payment - Schedule of Weighted Average Exercise Price and Weighted Remaining Contractual Life for Outstanding Warrants (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/ShareBasedPaymentSummaryOfFairValuesForWarrantGrantsDetail" id="ShareBasedPaymentSummaryOfFairValuesForWarrantGrantsDetail">
<link:definition>1057 - Disclosure - Share-based Payment  - Summary of Fair Values for Warrant Grants (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://ascendispharma.com/role/ShareBasedPaymentSummaryOfShareBasedPaymentDetail" id="ShareBasedPaymentSummaryOfShareBasedPaymentDetail">
<link:definition>1058 - Disclosure - Share-Based Payment - Summary Of Share Based Payment (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
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<link:definition>1059 - Disclosure - Share-Based Payment - Additional Information (Detail)</link:definition>
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</schema>
